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A new approach for the support of your patients in treating depression

deprexis® is an online psychotherapy program that provides an effective, individualized, and flexible treatment for depressive symptoms.

deprexis® an innovative approach for the treatment of depression

What is deprexis® ?

deprexis® is an online psychotherapy program based on documented methods of Cognitive Psychotherapy. Its efficacy has been demonstrated in 12 randomized controlled trials (RCTs) with more than 6,500 patients. In these studies, deprexis® was used as a stand alone or in combination with other modern methods of treating depression, such as antidepressants and/or face to face psychotherapy. If you want more information, you can see the clinical studies below.


Who developed deprexis® ?

deprexis® was developed by a multidisciplinary team of clinical psychologists, physicians, software engineers, graphic artists, and others at Gaia AG, Hamburg, Germany, a company specialized in research and development in e-Health. Servier has the exclusive rights for the promotion and distribution of deprexis® worldwide.

How does deprexis® interact with patients ?

deprexis® is tailored to each individual: users browse the program by choosing from predefined response options and the next content is tailored to suit the previously expressed needs and preferences (Meyer et al., 2009). The display order of the content may vary, as well as the detail, depending on the preferences of the user. Text sections are also added or omitted, depending on the user’s personal choice, and some dialogues are only shown to those who have similar interests. There are 11 modules, based on the theory of Cognitive Psychotherapy.

How can deprexis® help patients with depression?

Doctors and psychotherapists using deprexis® report the simple and varied application capabilities of the program. The HCP works with his patient independently with his own method and in combination with deprexis®, helps his patient to develop a basic understanding of his condition. deprexis® can be used for psycho-education, as well as for repetition and use, allowing the HCP to devote more time to personal sessions to process individual patient issues.
The goal of deprexis® is not to replace ersonal and face to face therapy, nor to be the miracle treatment for all patients.

Keys of deprexis®






times per week



How can the patient obtain access to deprexis®?


The patient purchases an
access code on

the patient then registers in the program directly after the purchase

the patient is then able to start the therapy

during the therapy the patient can print their results and share them with his/her therapist

Clinical studies

deprexis® is a CE marked medical device. Software, in order to qualify for the CE marking as a medical device, must comply with a set of specific regulations and laws (e.g. regulations on data security, technical functionality and management of adverse events ). The fact that a medical device has CE marking gives the HCP the certainty that the program is safe and operative as intended, because manufacturers of medical devices are legally obliged to ensure that they meet these conditions.
deprexis® is a program based on documented data, as its effectiveness has been demonstrated in eleven randomized controlled trials (RCTs). In these studies, deprexis was used alone or in combination with other modern methods of treating depression, such as antidepressants and / or psychotherapy. You can see the clinical studies below. (By Clicking on the study, you will be redirected to the publication.)


Effectiveness of a Novel Integrative Online Treatment for Depression (deprexis): Randomized Controlled Trial. Meyer, B., et al. J Med Internet Res 2009, 11 (2): e15. Doi 10.2196 / jmtr.1151.

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Internet-Based Treatment of Depression: A Randomized Controlled Τrial Comparing Guided with Unguided Self-Help. Berger et al., Cognitive Behavior Therapy 2011, 40 (4): 251-266.

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A randomized controlled trial of internet-based therapy in depression. Moritz et al., Behavior Research and Therapy 2012, 50: 513-521.

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An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial. Fischer, A., et al. Lancet psychiatry. 2015; 2 (3): 217-223.

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Efficacy of a psychological online intervention for depression in people with epilepsy: A randomized controlled trial.
Schröder et al., Epilepsy 2014, 55 (12): 2069-2076.

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Effects of an Internet intervention (deprexis) on severe depression symptoms: Randomized controlled trial.
Meyer, B., et al., Internet Interventions. 2015; 2 (1): 48-59.

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Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
Klein, JP, et al., Psychother Psychosome, 2016. 85 (4): 218-28.

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Effectiveness of an Internet Intervention (deprexis) for Depression in a United States Adult Sample: A Parallel-Group Pragmatic Randomized Controlled Trial.
Beevers, C. G., et al., Online First Publication, February 23, 2017.

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Effectiveness of an individually-tailored computerised CBT programme (deprexis) for depression: A meta-analysis.
Twomey C et al., Psychiatry Res 2017; 256: 371-377. doi: 10.1016 / j.psychres.2017.06.08 [Epub ahead of print].

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Online Self-Help as an Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach
Zwerenz R et al., Online Self-Help as to Add-On to Inpatient Psychotherapy: Efficacy of a New Blended Treatment Approach. Psychotherapy and psychosomatics. 2017; 86: 341-50.

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Evaluating an e-mental health program (deprexis) as an adjunctive treatment tool in psychotherapy for depression: Results of a pragmatic randomized controlled trial.
Berger T, Krieger T, Sude K, Meyer B, et al. Journal of Affective Disorders. 2018; 227: 455-62.

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Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms A Meta-analysis of Individual Participant Data.
Karyotaki E et al., Published online February 22, 2017 JAMA Psychiatry. doi:10.1001/jamapsychiatry.2017.0044.

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